• Get a good night’s sleep before a long drive.
• Get off the road if you notice any of the warning signs of fatigue.
• Take a nap – find a safe place to take a 5 to 20-minute nap.
• Consume caffeine – the equivalent of 2 cups of coffee can increase alertness for several hours, but DO NOT rely on it for long periods.
• Try consuming caffeine before taking a short nap to get the benefits of both.
• Drive with a friend. A passenger who remains awake can help watch for signs of fatigue in the driver and can take a turn driving, if necessary.
• Always wear your seatbelt.
Source: http://drowsydriving.org/about/detection-and-prevention/